We now know that when blood sugar is elevated, it binds to protein and forms what is called AGEs or Advanced Glycation End Products. These AGEs then turn on inflammation by leading to leakiness of the gut, which is what affects the brain the most. This is the toxic effect of blood sugar as it relates to the brain. AGEs and Leaky Gut
23/1/2019 Advanced Glycation End-Products (AGEs) are proteins, lipids, or nucleic acids that are irreversibly cross-linked with reducing sugars. While AGEs are produced in small amounts with aging, their production is markedly increased in the setting of hyperglycemia both in cellular and extracellular compartments, especially in richly vascularized organs such as the kidney. 53 While there are currently no clear guidelines on what would be a safe advanced glycation end product intake, a high-AGE diet is often seen as anything over 15,000 AGE kilounits (kU) daily, 15000 kU being the average consumption in New-York. Therefore, anything under that is low. Advanced glycation end products, also known as glycotoxins, are a diverse group of highly oxidant compounds with pathogenic significance in aged-chronic disease, including diabetes, cardiovascular
1. Basta G, Schmidt AM, De Caterina R. Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res. 2004 Sep 1;63(4):582-92. PMID: 15306213 2.
Sep 18, 2019 What are advanced glycation end products, and why do they matter for your health? Check out So NADPH-dependent aldo-keto reductases. Aug 17, 2017 in a series of advanced glycation end products (AGEs) (Thornal- ley, 1996). MG and associated AGEs are linked to several aging-.
Sep 18, 2019 What are advanced glycation end products, and why do they matter for your health? Check out So NADPH-dependent aldo-keto reductases.
Advanced Glycation End-products, or AGEs are products of normal dietary metabolism in all animals and to a much lesser extent, plants as well. There are hundreds of different types of AGEs and although this rowdy gang behaves like oxidants with the potential to damage proteins such as collagen, DNA and our cells, our antioxidant system under normal conditions, does a good job of neutralizing and excreting most of them in our urine.
1. Basta G, Schmidt AM, De Caterina R. Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res. 2004 Sep 1;63(4):582-92. PMID: 15306213 2.
Reduction of lipid peroxidation products and advanced glycation end-product precursors by cyanobacterial aldo-keto reductase AKR3G1—a founding member of the AKR3G subfamily. Hintzpeter J (1), Martin HJ (2), Maser E (2). BACKGROUND: Advanced glycation end products (AGEs) are derivative compounds generated from non-enzymatic glycosylation and oxidation. In comparison with glucose-derived AGEs (Glu-AGEs), glyceraldehyde-derived AGEs (Glycer-AGEs) have stronger toxicity to living systems. In this study, we compared the effects of AGE stands for “advanced glycation end-products.” These are compounds that naturally form in our bodies from the chemical reaction of sugars with proteins.
Advanced Glycation End-Products (AGEs) are proteins, lipids, or nucleic acids that are irreversibly cross-linked with reducing sugars. While AGEs are produced in small amounts with aging, their production is markedly increased in the setting of hyperglycemia both in cellular and extracellular compartments, especially in richly vascularized organs such as the kidney. 53
Sep 18, 2019 What are advanced glycation end products, and why do they matter for your health? Check out So NADPH-dependent aldo-keto reductases. Aug 17, 2017 in a series of advanced glycation end products (AGEs) (Thornal- ley, 1996). MG and associated AGEs are linked to several aging-. Oct 3, 2012 There are low molecular Maillard products such as aldehydes, ketones, acryl amides, and AGEs, as well as high molecular products such as Nov 8, 2016 Cerebral Ketone Body Oxidation Is Facilitated by a High Fat Diet Enriched with Advanced Glycation End Products in Normal and Diabetic Rats.